Meloxicam is not a medication that I would change the dose on or give every 12 hours. It is extremely hard on the GI tract. It also has to have time to cycle through the hepatic and renal systems. Giving doses every 12 hours doesn't allow this to happen. I would caution against meloxicam twice daily. Buprenorphine is a great drug for break through pain and given a lower doses will cut back on the sedative effects. I'm not wanting to start a debate about Meloxicam, but it's a drug with potentially severe side effects. And I don't think it's worth the risk. Don't get me wrong it's great for its anti-inflammatory and pain properties.