For the most part, guinea pigs will always be adverse to being picked up. Some are better than others though. One of my girls still runs and hids most of the time when I come up to the cage but the other is more relaxed. However, she will still struggle sometimes when I go to pick her up. Once they are out of the cage for floor time or cuddle time they should relax as long as they feel safe. Young pigs also tend to be more wiggly and jumpy than older ones. You just have to be patient with them and eventually they will warm to you
